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Detecting Rheumatoid Arthritis

JOINTstat

When your immune system attacks your joints, the daily pain, stiffness and swelling can go undiagnosed for months causing permanent damage. Quickly and accurately diagnosing rheumatoid arthritis can prevent damage and improve long-term quality of life.

How is the test performed?

Blood sample

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Effective August 6th, 2019, we will be removing the JOINTstat™ test for arthritis from the LifeLabs test menu. This decision follows a recent review of our testing menu, which is done periodically to ensure it reflects the clinical needs of patients and health care practitioners. 

At this time, no other test will be added to replace JOINTstat™.

Those looking to access the test are asked to contact Augurex, the parent company of JOINTstat™, through one of the following methods:

Until August 6th, patients and physicians can continue to obtain JOINTstat™ through LifeLabs locations as usual. 

Rheumatoid arthritis (RA) is an autoimmune disease where the body’s immune system – which normally functions to protect you against infections – mistakenly attacks the lining of the joints.

RA causes redness, pain, swelling or a hot (or warm) feeling in the lining of a joint and can also affect other internal organs such as the eyes, lungs or heart. Each year, about 1 percent of Canadians are affective by RA. If left untreated RA can create debilitating and permanent joint damage.

While the causes of RA are not completely clear, we know that its presence can be detected by a specific protein in your blood known as 14-3-3η. While this protein is present in everybody, it’s usually undetectable and inside cells. In patients with RA, this protein in pushed outside the cells and can be measured in your blood stream.

JOINTstat is a simple blood test used to detect the presence of the RA protein in your blood stream. A positive JOINTstat test complements a clinical assessment for the diagnosis of RA. It is also helpful in measuring the progression of RA. Studies have shown that higher RA protein levels correspond with a more aggressive state of the disease.

Additional information can be found in our JOINTstat test brochure here.

Effective August 6th, 2019, we will be removing the JOINTstat™ test for arthritis from the LifeLabs test menu. This decision follows a recent review of our testing menu, which is done periodically to ensure it reflects the clinical needs of patients and health care practitioners. 

At this time, no other test will be added to replace JOINTstat™.

Those looking to access the test are asked to contact Augurex, the parent company of JOINTstat™, through one of the following methods:

Until August 6th, patients and physicians can continue to obtain JOINTstat™ through LifeLabs locations as usual. 

​JOINTstat is a simple blood test used for the diagnosis of rheumatoid arthritis(RA). The test measures the levels of 14-3-3 (eta) protein in the blood to assist with the diagnosis of RA. The 14-3-3 protein is not normally present in the blood of healthy individuals. In the healthy state, 14-3-3 is present only inside of cells where it is involved in important biological processes. In patients with RA, 14-3-3 is pushed outside the cells where it causes harmful effects and where it is measurable in blood. In particular, 14-3-3 stimulates the production of factors that cause inflammation and joint damage.

When the JOINTstat test is used together with other standard laboratory tests like rheumatoid factor (RF) and anticyclic citrullinated protein (Anti-CCP) it complements your clinical assessment of a patient.

Additional information can be found in our JOINTstat test brochure here.

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