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Rheumatoid Arthritis


JOINTstat is a blood test used to diagnose Rheumatoid Arthritis. The test measures a protein in the blood that is involved in biochemical pathways that lead to inflammation and joint degradation. When used together with other standard laboratory tests like rheumatoid factor (RF) and anti-cyclic citrullinated protein (anti-CCP also known as ACPA) JOINTstat™ complements your doctor’s clinical assessment to get a biochemical view of what is going on in your body.


What is Rheumatoid Arthritis?

Rheumatoid arthritis (RA) is a chronic autoimmune, inflammatory condition that causes pain, swelling, and stiffness in the joints. If left untreated RA may cause irreversible joint damage. It is one of many different types of arthritis and fortunately, one for which treatments available.

What are the warning signs?

RA tends to begin slowly with minor symptoms that come and go, usually on both sides of the body, and progress over a period of weeks. It typically affects the joints in hands and feet, but may also affect other joints in your body. In addition to joint problems, RA may affect other body systems such as the heart, lungs, eyes or skin. Symptoms include:

  • Warm, swollen and tender joints
  • Daily joint stiffness in the morning
  • Fatigue, fever and weight loss
  • Symmetric symptoms i.e. those present on both sides of the body

Who should be tested?

Anyone who experiences symptoms such as fatigue and morning stiffness of the small joints of the hands and feet should consider getting tested with JOINTstat. Particular care should be taken by those with family history of RA and women, as they are 2 to 3 times more likely to develop rheumatoid arthritis than men

What is JOINTstat™?

JOINTstat is a simple blood test used for the diagnosis of RA. When the JOINTstat test is used together with other standard laboratory tests like rheumatoid factor (RF) and anti-cyclic citrullinated protein (Anti-CCP) it complements your healthcare provider’s clinical assessment to obtain a biochemical view of what is going on in your body.

How do I get tested?

Visit your healthcare provider and obtain a “JOINTstat Test Requisition.” Bring this requisition with you to a LifeLabs Patient Service Center where your blood sample will be collected. To minimize your wait time, take advantage of our appointment booking service

How is it used?

The JOINTstat test measures the levels of 14-3-3 (eta) protein in the blood to assist with the diagnosis of RA. The 14-3-3 protein is not normally present in the blood of healthy individuals. In the healthy state, 14-3-3 is present only inside of cells where it is involved in important biological processes. In patients with RA, 14-3-3 is pushed outside the cells where it causes harmful effects and where it is measurable in blood. In particular, 14-3-3 stimulates the production of factors that cause inflammation and joint damage.

What type of sample is required?

JOINTstat test is done on a blood sample.

How long will it take to get my results?

Test results will be available approximately 2 weeks after your sample collection. If the test indicates an abnormal result, your healthcare provider will contact you.

What if the results are abnormal?

An abnormal test result suggests you should be considered for a referral to a rheumatologist, prior to the onset of significant joint damage. JOINTstat provides biological-level information in regards to active joint damage, and provides your healthcare provider information to support their clinical assessment of possible RA.

How is the test performed?

JOINTstat™ is a blood test.

How much does it cost?


When will I get my results?

Test results will be available within 2 weeks.

How to Order

Did You Know?

When caught and treated early, Rheumatoid arthritis outcomes can be greatly improved.

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