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LifeLabs supports over 19 million patient visits annually, performing over 100 million tests.
LifeLabs is Canada’s largest community laboratory testing services provider.
HPV or human papillomavirus is a group of more than 150 related viruses, known as HPV types. Some HPV types can lead to cancer and are usually referred to as high-risk HPV types or HrHPV. Men and women can get cancer of mouth / throat, and anus / rectum caused by HPV infections. Men can also get penile HPV cancer. In women, HPV infections are the primary cause cervical, vaginal, and vulvar HPV cancers.
HPV is transmitted through intimate skin-to-skin contact and the most common way to contract this infection is through sexual intercourse. You can get HPV by having vaginal, anal, or oral sex with someone who has the virus. HPV is so common that nearly 9 out of 10 men and women get it at some point in their lives. HPV can be passed even when an infected person has no signs or symptoms. You can develop symptoms years after being infected, making it hard to know when you first became infected.
For women, HPV can remain undetected in your cervical cells for a long period of time without any warning signs or symptoms. Fortunately, most women are able to fight off this infection before it causes any health issues. It’s only when the high-risk HPV types don’t go away that abnormal cervical cells can develop.
Virtually all cases of cervical cancer are caused by HPV, and just two HrHPV types, 16 and 18, are responsible for about 70% of all cases. HPV associated cancer usually does not have symptoms until it is quite advanced, very serious and hard to treat. For this reason, it is important for women to get regular screening for cervical cancer.
Cervical cancer is one of the few cancers that can actually be prevented. Cervical cancer screening can find early signs of disease so that problems can be treated early, before they ever turn into cancer.
Being HPV-positive does not mean you have cervical cancer. HPV testing is the first step to measure your level of risk of developing cervical cancer and to rule out high-risk HPV infections, so it’s important to get this test done as part of your regular cervical screening.
1500 women in Canada are annually diagnosed with cervical cancer, and approximately 400 die from this disease.
There are more than 150 different types of HPV and approximately 40 different HPV types that can infect the human genital cells. However, only a subset of 13 to 18 of these types is considered highrisk for the development of cervical cancer and its precancerous state.
Cervical cancer can be detected with routine cervical cancer screening (Pap test) and follow-up of abnormal results with HPV test. At LifeLabs Ontario, we are able to conduct Pap and HPV tests from the same sample, so you do not need to undergo the collection procedure twice. At LifeLabs British Columbia, we offer HPV test as a standalone test to all doctors, and the collection procedure is exactly the same as that of a Pap.
Anyone who has ever been sexually active (that is, engaged in skin-to-skin sexual conduct, including vaginal, anal, or oral sex) can get HPV. HPV is easily passed between partners through sexual contact. Someone can have an HPV infection even if they have no symptoms and their only sexual contact with an HPV-infected person happened many years ago.
Women over the age of 30 should get the HPV test done as part of their routine cervical screening, along with the Pap test. This is called as HPV Cytology Co-testing, and informs you of your HPV status.*
Women over the age of 30 who have an abnormal Pap result can get an HPV test done to assess whether they are HPV positive, and to determine if it’s high-risk HPV. This is called Reflex HPV testing with cytology, and equips you and your doctor to plan further testing.
Women under 30 generally do not require the HPV test as their HPV infections tend to be temporary and are unlikely to result in abnormal cervical changes. However, if their Pap result is abnormal – they should talk to their healthcare provider about HPV testing.
* Testing guidelines change based on your province. In BC, LifeLabs doesn’t offer HPV Cytology Co-testing however, the HPV test is offered on its own in all provinces. Your HPV result should be interpreted with your Pap result to determine your cervical cancer risk. Talk to your doctor today to get screened for high-risk HPV.
Ask your healthcare provider about getting the HPV test as part of your routine screening. It can be requested at the same time as your regular Pap test. Your doctor will use the same collection kit to take a cervical cell sample.
A Pap test looks for signs of abnormal changes in the cervical cells which may or may not be the result of an HPV infection. The Pap test does not look directly for the HPV virus. A stand-alone Pap test may miss some abnormal cell growth, or may not detect it early enough to prevent cervical cancer. Pap test should be considered an early stage screening test to identify women in need of further testing or treatment, however it should not be considered a replacement for the HPV test.
A normal Pap results does not mean you are cancer-free. Up to one-third of cervical cancer cases are of women who have a negative / clear Pap result.
The HPV test involves detecting the presence of an HPV virus, as well as classifying the HPV type as high-risk or low risk. Furthermore, HPV testing at LifeLabs offers genotyping for detetction of the 14 high risk HPV genotypes, and specifically identifies HPV 16 and 18- the two high risk types most commonly associated with cervical cancer.
If your HPV test is negative and your Pap is clear, you can return for a routine HPV screening at your next scheduled Pap screening.
If your HPV test is negative but your Pap is abnormal or inconclusive, your healthcare provider might recommend additional testing. In some cases, your provider might recommend a procedure called colposcopy that allows a more detailed examination of your cervical cells.
If high-risk HPV types are detected, your doctor may recommend further testing based on information provided by the results, including a possible colposcopy. While nearly all cervical cancers are associated with HrHPV, the majority of the high risk infections DO NOT develop into cancer. Please consult with your doctor who can advise on the most appropriate course of action.
The HPV test is performed on cervical cells in the same manner as the Pap test. In Ontario, you can request your doctor to include the HPV test as part of your cervical screening. In other provinces, your doctor can help you determine whether to get HPV before or after your Pap test. No special preparation is necessary for this test. When HPV and Pap are requested together, it is referred to as Pap-HPV Co-testing.
Your provider might also indicate they prefer Reflex HPV testing on Pap – which means, we will test for HPV in case the Pap result was abnormal or inconclusive.
HPV test is not currently covered by provincial health insurance plans, but may be covered by your extended health plan. You are encouraged to check your coverage with your insurance provider.
At LifeLabs, HPV testing is done using Roche Cobas® HPV assay, which detects the presence of 14 high risk HPV types, and specifically identifies HPV16 and HPV18. The BD SurePath™ Pap collection devices are used to obtain the sample for Pap and / or HPV testing. These collection devices ensure an ideal amount of cervical cells are captured in the first collection.
In Ontario, we provide combined Pap and HPV results on the same report and store samples for up to 30 days from date of collection. This lets us perform the reflex HPV test on a sample when the Pap result was found to be abnormal / inconclusive, even if a few weeks have gone by since date of collection. In other provinces, HPV results are provided on their own.
Talk to your doctor today about getting the HPV test as your first step in cervical cancer screening!
Your healthcare provider will use a
LifeLabs collection kit to take a sample of
cervical cells for testing.
Your test results will be available to your
healthcare provider within 2 weeks of
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