How is it used?
MPO is used to help determine the risk of heart attack and stroke.
When is it ordered?
MPO is ordered for patients considered to be at borderline risk for heart attack or stroke based on their clinical history. Some of the risk factors for cardiovascular disease include:
- High blood pressure
- Physical inactivity
- Borderline or high cholesterol
- Family history
- Being overweight
- Metabolic syndrome
What does the test result mean?
Atherosclerosis, or hardening of the arteries, occurs due to a prolonged period of arterial inflammation. When the arteries are inflamed, lipids can deposit in the arterial walls and form a so-called 'vulnerable plaque'. Over time this plaque can rupture and be released into the blood stream where it can lead to heart attack or stroke. If elevated, MPO could point to the presence of a vulnerable plaque and a person's elevated risk for heart attack or stroke.1
Is there a charge for the test?
This test is not covered by the provincial health insurance plans, but it may be covered by extended health insurance plans. Contact LifeLabs to find out about the current fee for the test.
Is there anything else I should know?
50% of heart attacks occur in people with normal cholesterol levels and 68% of heart attacks occur in patients whose arteries are not narrow. This speaks to the need for more effective biomarkers for risk of heart attack.
- Heslop et al, 2010. Myeloperoxidase and C-Reactive Protein Have Combined Utility for Long-Term Prediction of Cardiovascular Mortality After Coronary Angiography. Journal of the American College of Cardiology; 55: 1102-1109
- Zhang R, Brennan M-L, Fu X, et al. Association between myeloperoxidase levels and risk of coronary artery disease. Journal of the American Medical Association. 2001;286(17):2136–2142.
- Meuwese MC, Stroes ESG, Hazen SL, et al. Serum myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals. The EPIC-Norfolk prospective population study. Journal of the American College of Cardiology. 2007;50(2):159–165