What is Being Tested?
Anti-Müllerian hormone (AMH) is a proteins produced by granulosa cells in ovarian follicles. Circulating levels of AMH plateau at approximately 25 years of age, begin to decline at approximately 30 years of age, and continue to decline throughout reproductive life. There is a positive correlation between circulating AMH levels and the number of remaining antral ovarian follicles.1,3 Therefore, circulating AMH levels may be used to provide an indication of the ovarian reserve. 1-4
The AMH levels are also used to predict age of menopause, confirm diagnosis of premature ovarian failure and predict likelihood of IVF success.1-4 AMH levels correlate positively with number of retrieved oocytes1 and low AMH levels predict a lower likelihood of follicle response. 1,3
Additionally, AMH levels may be used to assess risk of ovarian hyperstimulation syndrome (OHSS) caused by exaggerated response to gonadotropin treatment 2,3 and to help diagnose polycystic ovary syndrome (PCOS). 3,5